Metabolic effects of 20 kDa and 22 kDa human growth hormones on adult male spontaneous dwarf rats
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چکیده
منابع مشابه
Physiological and pharmacological regulation of 20-kDa growth hormone.
The 20-kDa growth hormone (GH) is generated from alternative splicing of the primary transcript of full-length 22-kDa GH. We have studied the regulation of 20-kDa GH over a range of pathophysiological conditions and in response to pharmacological stimulation using isoform-specific enzyme-linked immunosorbent assays (ELISAs). Mean 24-h levels of 20- and 22-kDa GH were higher in acromegaly and lo...
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15 صفحه اولRegulation of human GH receptor gene transcription by 20 and 22 kDa GH in a human hepatoma cell line.
The human GH gene is 1.7 kilobase pairs (kb) in length and is composed of five exons and four introns. This gene is expressed in the pituitary gland and encodes a 22 kDa protein. In addition to this predominant (75%) form, 5-10% of pituitary GH is present as a 20 kDa protein that has an amino acid (aa) sequence identical to the 22 kDa form except for a 15 aa internal deletion of residues 32-46 ...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2001
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1450791